Train Smarter With IMMUSE™

Train Smarter With IMMUSE™

A strong immune system is critical for good health and optimal performance in the gym, as well as post-exercise recovery. If your immune system is compromised and you get sick, it could set your training back as you spend more time in bed than in the squat rack. That’s why immune support is crucial – and over the last several years, it has become one of the top three reasons why people (lifters and non-lifters alike) buy supplements. Train smarter and give your immune system additional support with IMMUSE.*

During high-intensity training, the brain produces a cascade of hormones that boost energy levels but may also tax your immune system. Evidence suggests that prolonged periods of intense training suppress immune function, putting athletes’ health at risk. That’s why it’s important to give your immune system the extra support it needs during periods of high-intensity exercise, in addition to adequate rest and recovery, quality sleep, hydration, and proper post-exercise nutrition.

Kyowa Hakko’s IMMUSE (LC-Plasma) postbiotic proactively supports the immune system for exercise.* IMMUSE, a natural food and dietary ingredient, has been clinically shown to support exercise performance by supporting the immune system, and may also help reduce subjective symptoms caused by continuous training, such as fatigue and physical deconditioning.*

Supported by More Than 25 Studies

IMMUSE is a novel and patented strain of Lactococcus lactis that is supported by more than 25 studies including 11 human clinical trials – and the first lactic acid bacteria that has been clinically researched to directly activate pDCs, a rare subset of immune cells and leader of the immune system,* to provide comprehensive innate and adaptive immune support.* IMMUSE can be incorporated into a wide range of products designed to support immunity, productivity and overall performance including dietary supplements, cereals, protein bars and yogurts.

Kyowa Hakko: Leading the Way in Immune Health Research

IMMUSETM is backed by Kyowa Hakko, an international health ingredient manufacturer and a world leader in the development, manufacturing and marketing of nutraceuticals, pharmaceuticals, and food products. Part of Kyowa’s dedication to ongoing scientific research, quality management and consumer education, IMMUSE leads the way in immune health research.*

IMMUSE Under the Microscope

Supports exercise performance by activating immune system*

Researchers carried out a randomized, double-blind study on fifty-one male athletes part of a university sports club. (Accumulated subjective symptoms of physical condition and fatigue after exercise.) Individuals who consumed IMMUSE increased their respiratory health, followed by reduced fatigue level.*

Supports respiratory health*

Researchers carried out a randomized, double-blind study on 213 healthy subjects during the winter season. Measured over a 10-week period, individuals who consumed yogurts formulated with IMMUSE increased respiratory health.*


Postbiotics are inactivated (non-viable) probiotics with health benefits similar to live probiotics. Postbiotics also provide the added advantage that they have a longer shelf-life and play a vital role in improving immune health by supporting immune-modulation benefits.* IMMUSETM, a patented postbiotic, is a heat-killed Lactococcus lactis strain Plasma that has been shown to provide immune support at a cellular level.* The postbiotics market is expected to reach $24 million by 2029.

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


1. Komano Y, et. al. Efficacy of heat-killed Lactococcus lactis JCM 5805 on immunity and fatigue during consecutive high intensity exercise in male athletes: A randomized, placebo-controlled, double-blinded trial. J Int Soc Sports Nutr. 2018;15(1):39.

2. Sugimura T, et. al. Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus. British Journal of Nutrition. 2015;114(5):727-733.

3. Postbiotics Market is Projected to Reach $24 Million by 2029 – Market Size, Share, Forecasts, & Trends Analysis Report with COVID-19 Impact by Meticulous Research. PR Newswire, March 6, 2023.

4. Linxi Ma et al. Postbiotics in Human Health: A Narrative Review. Nutrients 2023; Jan 6;15(2):291. doi: 10.3390/nu15020291.

5. Lene Salimans et al. The effect of resistance exercise on the immune cell function in humans: A systematic review. Exp Gerontol 2022; Jul;164:111822. doi: 10.1016/j.exger.2022.111822. Epub 2022 Apr 29.

6. Laura Wosinska et al. The Potential Impact of Probiotics on the Gut
Microbiome of Athletes. Nutrients 2019; Sep 21;11(10):2270. doi: 10.3390/nu11102270.

7. Wiley. Excessive exercise may damage the gut. ScienceDaily. ScienceDaily, 7 June 2017.

8. Linxi Ma et al. Postbiotics in Human Health: A Narrative Review. Nutrients 2023; Jan 6;15(2):291. doi: 10.3390/nu15020291.

9. Bing Liang et al.  The Current and Future Perspectives of Postbiotics. Probiotics Antimicrob Proteins 2023; Feb 10;1-18. doi: 10.1007/s12602-023-10045-x.

10. Anthony C Hackney and Kristen J Koltun. The immune system and overtraining in athletes: clinical implications. Acta Clin Croat 2012; Dec;51(4):633-41.

11. Neil P Walsh. Nutrition and Athlete Immune Health: New Perspectives on an Old Paradigm. Sports Med 2019; Dec;49(Suppl 2):153-168. doi: 10.1007/s40279-019-01160-3.

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